Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation.

Developmental biology - 15 Sept 2010

Kleinschmit Adam, Koyama Takashi, Dejima Katsufumi, Hayashi Yoshiki, Kamimura Keisuke, Nakato Hiroshi

Abstract excerpt

Heparan sulfate proteoglycans (HSPGs) play critical roles in the distribution and signaling of growth factors, but the molecular mechanisms regulating HSPG function are poorly understood. Here, we characterized Sulf1, which is a Drosophila member of the HS 6-O endosulfatase class of HS modifying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to In Situ Hybridization, Fluorescence
Share to Morphogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sulfatases

Share to Sulfotransferases

Share to Up-Regulation

Share to Wings, Animal

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20637191
DOI: 10.1016/j.ydbio.2010.07.006
PMCID: PMC2963650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20637191-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation.PMID 20637191Read ↗

Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation.Semantic proximity Read ↗

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling.Semantic proximity Read ↗

Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling.Semantic proximity Read ↗

Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase.Semantic proximity Read ↗

Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.Semantic proximity Read ↗

In vivo manipulation of heparan sulfate structure and its effect on Drosophila development.Semantic proximity Read ↗

Roles of heparan sulfate sulfation in dentinogenesis.Semantic proximity Read ↗

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.Semantic proximity Read ↗

Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.Semantic proximity Read ↗

Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid.Semantic proximity Read ↗

Mammalian brain morphogenesis and midline axon guidance require heparan sulfate.Semantic proximity Read ↗

Developmental roles of heparan sulfate proteoglycans in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.