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Article

Heparan sulfate polymerization in Drosophila.

The Journal of biological chemistry - 27 Jan 2006

Izumikawa Tomomi, Egusa Noriyuki, Taniguchi Fumiyasu, Sugahara Kazuyuki, Kitagawa Hiroshi

Abstract excerpt

The formation of heparan sulfate (HS) chains is catalyzed by glycosyltransferases encoded by EXT (hereditary multiple exostosin gene) family members. Genetic screening for mutations affecting morphogen signaling pathways in Drosophila has identified three genes, tout-velu (ttv), sister of tout-velu (sotv), and brother of toutvelu (botv), which encode homologues of human EXT1, EXT2, and EXTL3, respectively. So...

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Identifiers

PMID: 16303756
DOI: 10.1074/jbc.M509138200

Genes

EXT1
EXT2
EXTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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