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Article

In vivo analysis of Drosophila chondroitin sulfate biosynthetic genes.

The Journal of biological chemistry - 1 Nov 2025

Izumikawa Tomomi, Moriya Ayano, Nakato Eriko, Yamamoto Kako, Sano Raiki, Akiyama Takuya, Kinoshita-Toyoda Akiko, Toyoda Hidenao, Nakato Hiroshi

Abstract excerpt

Chondroitin sulfate (CS) is an evolutionarily conserved class of glycosaminoglycans and is found in most animal species. Previous studies of CS-deficient Drosophila models, Chondroitin sulfate synthase (Chsy), and Chondroitin polymerizing factor (Chpf) mutants demonstrated the importance of CS in the structural integrity of the basement membrane and organ shape maintenance. However, biosynthetic mechanisms of...

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PMID: 41062067
DOI: 10.1016/j.jbc.2025.110783
PMCID: PMC12630343

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CS

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