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Article

Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling.

The Journal of cell biology - 11 Sept 2006

Kamimura Keisuke, Koyama Takashi, Habuchi Hiroko, Ueda Ryu, Masu Masayuki, Kimata Koji, Nakato Hiroshi

Abstract excerpt

Specific sulfation sequence of heparan sulfate (HS) contributes to the selective interaction between HS and various proteins in vitro. To clarify the in vivo importance of HS fine structures, we characterized the functions of the Drosophila HS 2-O and 6-O sulfotransferase (Hs2st and Hs6st) genes in FGF-mediated tracheal formation. We found that mutations in Hs2st or Hs6st had unexpectedly little effect on...

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Identifiers

PMID: 16966419
DOI: 10.1083/jcb.200603129
PMCID: PMC2064332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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