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Article

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.

PLoS genetics - 1 Feb 2022

Habicher Judith, Varshney Gaurav K, Waldmann Laura, Snitting Daniel, Allalou Amin, Zhang Hanqing, Ghanem Abdurrahman, Öhman Mägi Caroline, Dierker Tabea, Kjellén Lena, Burgess Shawn M, Ledin Johan

Abstract excerpt

Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large number of enzymes involved in their biosynthesis have made CS/DS function a challenging problem to study genetically. In our study, we generated loss-of-function alleles in zebrafish genes encoding CS/DS biosynthetic enzymes and characterized the effect on development in single and double...

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Identifiers

PMID: 35192612
DOI: 10.1371/journal.pgen.1010067
PMCID: PMC8896900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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