Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.

Pharmacogenetics and genomics - 1 Dec 2013

Karnes Jason H, Gong Yan, Pacanowski Michael A, McDonough Caitrin W, Arwood Meghan J, Langaee Taimour Y, Pepine Carl J, Johnson Julie A, Cooper-Dehoff Rhonda M

Abstract excerpt

OBJECTIVE: Thiazide diuretics have been associated with increased risk for new onset diabetes (NOD), but pharmacogenetic markers of thiazide-induced NOD are not well studied. Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent the strongest and most reproducible genetic associations with diabetes. We investigated the association of tag SNPs in TCF7L2 with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antihypertensive Agents
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to Diabetes Mellitus, Type 2

Share to Hydrochlorothiazide

Share to Hypertension

Share to Transcription Factor 7-Like 2 Protein

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 24128935
DOI: 10.1097/FPC.0000000000000012
PMCID: PMC3893755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.PMID 24128935Read ↗

Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects.Semantic proximity Read ↗

KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment.Semantic proximity Read ↗

Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.Semantic proximity Read ↗

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.Semantic proximity Read ↗

Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.Semantic proximity Read ↗

Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.Semantic proximity Read ↗

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African AmericansSemantic proximity Read ↗

Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.Semantic proximity Read ↗

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.Semantic proximity Read ↗

A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.Semantic proximity Read ↗

Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.Semantic proximity Read ↗

Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.