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Article

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.

Pharmacogenomics - 1 Apr 2018

Ala-Mutka Eero M, Rimpelä Jenni M, Fyhrquist Frej, Kontula Kimmo K, Hiltunen Timo P

Abstract excerpt

AIM: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration. PATIENTS & METHODS: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from the GENRES study. Replication analyses were performed in 465 Finns from the LIFE study. RESULTS: In GENRES, we identified 31 loci associated with...

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Source

Identifiers

PMID: 29580174
DOI: 10.2217/pgs-2017-0184

Genes

ABCC4
BRINP3
PADI4
VEGFC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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