Article
Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.
The pharmacogenomics journal - 1 Oct 2013
Karnes J H, McDonough C W, Gong Y, Vo T T, Langaee T Y, Chapman A B, Gums J G, Beitelshees A L, Bailey K R, Del-Aguila J L, Boerwinkle E A, Pepine C J, Turner S T, Johnson J A, Cooper-DeHoff R M
Abstract excerpt
Thiazide-induced potassium loss may contribute to new onset diabetes (NOD). KCNJ1 encodes a potassium channel and one study observed that a KCNJ1 single-nucleotide polymorphism (SNP) was associated with changes in fasting glucose (FG) during hydrochlorothiazide (HCTZ) treatment. We used linear regression to test association of KCNJ1 SNPs and haplotypes with FG changes during HCTZ treatment in the Pharmacogenomic...
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