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Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans

12 Feb 2013

Abstract excerpt

Hydrochlorothiazide (HCTZ) is one of the most widely prescribed antihypertensive medications. Although it is well known that HCTZ is associated with hyperglycemia and hypertriglyceridemia, the mechanisms underlying these adverse effects are not well understood. We performed a genome-wide association study and meta-analysis of the change in fasting plasma glucose and triglycerides in response to HCTZ from two...

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PMID: 23400010
DOI: 10.1038/tpj.2013.3

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