Article
Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.
Journal of hypertension - 1 Apr 2013
McDonough Caitrin W, Burbage Sarah E, Duarte Julio D, Gong Yan, Langaee Taimour Y, Turner Stephen T, Gums John G, Chapman Arlene B, Bailey Kent R, Beitelshees Amber L, Boerwinkle Eric, Pepine Carl J, Cooper-DeHoff Rhonda M, Johnson Julie A
Abstract excerpt
OBJECTIVE: Single-nucleotide polymorphisms (SNPs) in NEDD4L may influence the ability of the NEDD4L protein to reduce epithelial sodium channel expression. A variant in NEDD4L, rs4149601, was associated with antihypertensive response and cardiovascular outcomes during treatment with thiazide diuretics and β-blockers in a Swedish population. We sought to further evaluate associations between NEDD4L polymorphisms,...
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