Article
Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.
The pharmacogenomics journal - 1 Jan 2018
Chang S-W, McDonough C W, Gong Y, Johnson T A, Tsunoda T, Gamazon E R, Perera M A, Takahashi A, Tanaka T, Kubo M, Pepine C J, Johnson J A, Cooper-DeHoff R M
Abstract excerpt
We conducted a discovery genome-wide association study with expression quantitative trait loci (eQTL) annotation of new-onset diabetes (NOD) among European Americans, who were exposed to a calcium channel blocker-based strategy (CCB strategy) or a β-blocker-based strategy (β-blocker strategy) in the INternational VErapamil SR Trandolapril STudy. Replication of the top signal from the SNP*treatment interaction...
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