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Article

ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

16 Sept 2013

Abstract excerpt

Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box-binding protein 1 (XBP1), confer genetic risk for inflammatory bowel disease. We report here that hypomorphic Xbp1 function instructs a multilayered regenerative response in the intestinal epithelium. This is characterized by intestinal stem cell...

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PMID: 24043762
DOI: 10.1084/jem.20122341

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