Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.

Molecular and cellular biology - 1 Dec 2013

Dachsel Justus C, Ngok Siu P, Lewis-Tuffin Laura J, Kourtidis Antonis, Geyer Rory, Johnston Lauren, Feathers Ryan, Anastasiadis Panos Z

Abstract excerpt

The role of RhoA in promoting directed cell migration has been complicated by studies showing that it is activated both in the front and the rear of migrating cells. We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain and breast tumor cells. This function of Syx is mediated by the selective activation of the RhoA downstream effector...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Cell Shape

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Focal Adhesions

Share to Formins

Share to Guanine Nucleotide Exchange Factors

Share to Microtubules

Share to Protein Stability

Share to rho-Associated Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 24126053
DOI: 10.1128/MCB.00565-13
PMCID: PMC3889543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.PMID 24126053Read ↗

Regulation of Rho GTPases by RhoGDIs in Human CancersSemantic proximity Read ↗

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migrationSemantic proximity Read ↗

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration.Semantic proximity Read ↗

Cell Migration: Integrating Signals from Front to BackSemantic proximity Read ↗

Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.Semantic proximity Read ↗

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.Semantic proximity Read ↗

A Modular Platform for the Optogenetic Control of Small GTPase Activity in Living Cells Reveals Long-Range RhoA SignalingSemantic proximity Read ↗

Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctionsSemantic proximity Read ↗

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.Semantic proximity Read ↗

SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPasesSemantic proximity Read ↗

RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesisSemantic proximity Read ↗

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.