Article
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
Molecular biology of the cell - 1 Aug 2007
Prag Soren, Parsons Maddy, Keppler Melanie D, Ameer-Beg Simon M, Barber Paul, Hunt James, Beavil Andrew J, Calvert Rosy, Arpin Monique, Vojnovic Borivoj, Ng Tony
Abstract excerpt
Establishment of polarized cell morphology is a critical factor for migration and requires precise spatial and temporal activation of the Rho GTPases. Here, we describe a novel role of the actin-binding ezrin/radixin/moesin (ERM)-protein ezrin to be involved in recruiting Cdc42, but not Rac1, to lipid raft microdomains, as well as the subsequent activation of this Rho GTPase and the downstream effector...
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