Article
A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.
The Journal of cell biology - 2 Jan 2017
Sun Tianliang, Yang Lida, Kaur Harmandeep, Pestel Jenny, Looso Mario, Nolte Hendrik, Krasel Cornelius, Heil Daniel, Krishnan Ramesh K, Santoni Marie-Josée, Borg Jean-Paul, Bünemann Moritz, Offermanns Stefan, Swiercz Jakub M, Worzfeld Thomas
Abstract excerpt
Semaphorins comprise a large family of ligands that regulate key cellular functions through their receptors, plexins. In this study, we show that the transmembrane semaphorin 4A (Sema4A) can also function as a receptor, rather than a ligand, and transduce signals triggered by the binding of Plexin-B1 through reverse signaling. Functionally, reverse Sema4A signaling regulates the migration of various cancer cells...
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