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Article

SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases

10 Mar 2016

Abstract excerpt

Despite current advances in cancer research, metastasis remains the leading factor in cancer-related deaths. Here, we identify sorting nexin 9 (SNX9) as a new regulator of breast cancer metastasis. We detected an increase in SNX9 expression in human breast cancer metastases compared with primary tumors and demonstrated that SNX9 expression in MDA-MB-231 breast cancer cells is necessary to maintain their ability...

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PMID: 26960793
DOI: 10.1091/mbc.e16-02-0101

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