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Article

Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.

PloS one - 1 Mar 2010

Abhary Sotoodeh, Burdon Kathryn P, Kuot Abraham, Javadiyan Shahrbanou, Whiting Malcolm J, Kasmeridis Nicholas, Petrovsky Nikolai, Craig Jamie E

Abstract excerpt

BACKGROUND: Asymmetric dimethylarginine (ADMA), present in human serum, is an endogenous inhibitor of nitric oxide synthase and contributes to vascular disease. Dimethylarginine dimethylaminohydrolase (DDAH) is an ADMA degrading enzyme that has two isoforms: DDAHI and DDAHII. We sought to determine whether serum ADMA levels in type 2 diabetes are influenced by common polymorphisms in the DDAH1 and DDAH2 genes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20209122
DOI: 10.1371/journal.pone.0009462
PMCID: PMC2830883

Genes

DDAH1
DDAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.PMID 20209122Read ↗

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