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Article

DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender-dependent manner.

Molecular genetics & genomic medicine - 1 Jan 2020

Zhu Fasheng, Zhou Chi, Wen Zheng, Wang Dao Wen

Abstract excerpt

BACKGROUND: Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases, making it a contributing factor for diabetes. Endogenous ADMA is hydrolyzed by dimethylarginine dimethylaminohydrolase 1 (DDAH1), and a DDAH1 promoter -396 4N deletion/insertion polymorphism (DDAH1: -396_-395insGCGT) regulates its transcriptional activity. This study aimed to explore the association between this...

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Share to Amidohydrolases
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Mutagenesis, Insertional

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 31733101
DOI: 10.1002/mgg3.1011
PMCID: PMC6978400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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