Article
A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity.
PloS one - 1 Jan 2012
Andreozzi Francesco, Presta Ivan, Mannino Gaia Chiara, Scarpelli Daniela, Di Silvestre Sara, Di Pietro Natalia, Succurro Elena, Sciacqua Angela, Pandolfi Assunta, Consoli Agostino, Hribal Marta Letizia, Perticone Francesco, Sesti Giorgio
Abstract excerpt
BACKGROUND: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, which was associated with insulin resistance. Dimethylarginine dimethylaminohydrolase (DDAH) is the major determinant of plasma ADMA. Examining data from the DIAGRAM+ (Diabetes Genetics Replication And Meta-analysis), we identified a variant (rs9267551) in the DDAH2 gene nominally associated with type 2...
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