Article
Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes.
Journal of diabetes and its complications - 1 Jan 2000
Fogarty Rhys D, Abhary Sotoodeh, Javadiyan Shahrbanou, Kasmeridis Nicholas, Petrovsky Nikolai, Whiting Malcolm J, Craig Jamie E, Burdon Kathryn P
Abstract excerpt
Asymmetric dimethylarginine (ADMA) levels are elevated in diabetes and likely contribute to diabetic complications such as retinopathy and nephropathy. The DDAH enzymes are primarily responsible for ADMA metabolism. Polymorphisms in the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes have been previously associated with serum ADMA levels in type 2 diabetes (T2DM). We sought to determine whether they...
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