Article
Apolipoprotein E polymorphism modulation of asymmetric dimethylarginine in hypertensive patients is determined by renal function.
Lipids in health and disease - 20 Jan 2016
Marrocos Mauro Sergio Martins, Teixeira Andrei Alkmin, Quinto Beata Marie, Carmona Silmara de Melo, Kuniyoshi Mariana, Rodrigues Cassio Jose, Dalboni Maria Aparecida, Manfredi Silvia, Canziani Maria Eugênia, Batista Marcelo Costa
Abstract excerpt
BACKGROUND: Endothelial dysfunction is considered an early step of atherosclerotic vascular disease. Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase (NOS), plays a critical role in the process of atherosclerosis in a uremic environment. Increased plasma ADMA not only works as a cardiovascular morbidity biomarker but it is also involved in the genesis of atherosclerosis...
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