Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.

Diabetes care - 1 Jan 2014

Anderssohn Maike, McLachlan Stela, Lüneburg Nicole, Robertson Christine, Schwedhelm Edzard, Williamson Rachel M, Strachan Mark W J, Ajjan Ramzi, Grant Peter J, Böger Rainer H, Price Jackie F

Abstract excerpt

OBJECTIVE: To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS: Prevalent CVD was assessed in men and women aged 60-75...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Diabetes Mellitus, Type 2

Share to Diabetic Angiopathies

Share to Environment

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Identifiers

PMID: 24186881
DOI: 10.2337/dc13-0546

Genes

AGXT2
DDAH1
DDAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.PMID 24186881Read ↗

Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.Semantic proximity Read ↗

The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study.Semantic proximity Read ↗

Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.Semantic proximity Read ↗

Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes.Semantic proximity Read ↗

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.Semantic proximity Read ↗

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity.Semantic proximity Read ↗

DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender-dependent manner.Semantic proximity Read ↗

Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation.Semantic proximity Read ↗

ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis.Semantic proximity Read ↗

Effect of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study.Semantic proximity Read ↗

ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitusSemantic proximity Read ↗

DDAH gene and cardiovascular risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.