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Article

Mutant monocyte chemoattractant protein 1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopedic implant wear particles.

Journal of biomedical materials research. Part A - 1 Sept 2014

Yao Zhenyu, Keeney Michael, Lin Tzu-Hua, Pajarinen Jukka, Barcay Katherine, Waters Heather, Egashira Kensuke, Yang Fan, Goodman Stuart

Abstract excerpt

Wear particles generated from total joint replacements can stimulate macrophages to release chemokines, such as monocyte chemoattractant protein 1 (MCP-1), which is the most important chemokine regulating systemic and local cell trafficking and infiltration of monocyte/macrophages in chronic inflammation. One possible strategy to curtail the adverse events associated with wear particles is to mitigate migration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24123855
DOI: 10.1002/jbm.a.34981
PMCID: PMC4035458

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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