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Article

Suppression of NF-κB-induced chronic inflammation mitigates inflammatory osteolysis in the murine continuous polyethylene particle infusion model.

Journal of biomedical materials research. Part A - 1 Oct 2021

Utsunomiya Takeshi, Zhang Ning, Lin Tzuhua, Kohno Yusuke, Ueno Masaya, Maruyama Masahiro, Huang Ejun, Rhee Claire, Yao Zhenyu, Goodman Stuart B

Abstract excerpt

Wear particle-associated bone loss (periprosthetic osteolysis) constrains the longevity of total joint arthroplasty (TJA). Wear particles induce a prolonged upregulation of nuclear factor kappa B (NF-κB) signaling in macrophages and osteoclasts. Synthetic double-stranded oligodeoxynucleotides (ODNs) can prevent the binding of NF-κB to the promoter regions of targeted genes and inhibit genetic activation. We...

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Identifiers

PMID: 33779115
DOI: 10.1002/jbm.a.37175
PMCID: PMC8373802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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