Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of mouse macrophage polarization in vitro using IL-4 delivery by osmotic pumps.

Journal of biomedical materials research. Part A - 1 Apr 2015

Pajarinen Jukka, Tamaki Yasunobu, Antonios Joseph K, Lin Tzu-Hua, Sato Taishi, Yao Zhenyu, Takagi Michiaki, Konttinen Yrjö T, Goodman Stuart B

Abstract excerpt

Modulation of macrophage polarization is emerging as promising means to mitigate wear particle-induced inflammation and periprosthetic osteolysis. As a model for continuous local drug delivery, we used miniature osmotic pumps to deliver IL-4 in order to modulate macrophage polarization in vitro from nonactivated M0 and inflammatory M1 phenotypes towards a tissue regenerative M2 phenotype. Pumps delivered IL-4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Conditioned

Share to Interleukin-4

Share to Lipopolysaccharides

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Osmosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25044942
DOI: 10.1002/jbm.a.35278
PMCID: PMC4297266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of mouse macrophage polarization in vitro using IL-4 delivery by osmotic pumps.PMID 25044942Read ↗

Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype.Semantic proximity Read ↗

Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug DeliverySemantic proximity Read ↗

Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface.Semantic proximity Read ↗

Rethinking Regenerative Medicine: A Macrophage-Centered ApproachSemantic proximity Read ↗

Effects of aging upon the host response to implantsSemantic proximity Read ↗

Controlled release of cytokines using silk-biomaterials for macrophage polarization.Semantic proximity Read ↗

Barium titanate piezoelectric nanoparticles induce M1 polarization in mouse macrophages via ultrasound <i>in vitro</i>Semantic proximity Read ↗

A Novel <i>Ex Vivo</i> Approach for Investigating Profibrotic Macrophage Polarization Using Murine Precision-Cut Lung SlicesSemantic proximity Read ↗

Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries.Semantic proximity Read ↗

Macrophage phenotypes modulate neoangiogenesis and fibroblast profiles in synovial-like organoid cultures.Semantic proximity Read ↗

A Dual-Fluorescence Assay for Gene Delivery Vehicle Screening in Macrophages with an Inflammation-Inducible Reporter ConstructSemantic proximity Read ↗

Airway Delivery of Encapsulated Cytokine-Secreting Cells for Local Immunomodulation in Inflammatory Lung DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.