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Article

Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2016

Movila Alexandru, Ishii Takenobu, Albassam Abdullah, Wisitrasameewong Wichaya, Howait Mohammed, Yamaguchi Tsuguno, Ruiz-Torruella Montserrat, Bahammam Laila, Nishimura Kazuaki, Van Dyke Thomas, Kawai Toshihisa

Abstract excerpt

By binding to its chemokine receptor CXCR4 on osteoclast precursor cells (OCPs), it is well known that stromal cell-derived factor-1 (SDF-1) promotes the chemotactic recruitment of circulating OCPs to the homeostatic bone remodeling site. However, the engagement of circulating OCPs in pathogenic bone resorption remains to be elucidated. The present study investigated a possible chemoattractant role of macrophage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27082509
DOI: 10.1002/jbmr.2854
PMCID: PMC5010512

Genes

MIF
CXCR4
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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