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Article

The characterisation of monocyte responses to mediators released from osteoarthritic and periprosthetic tissues

2018-01-01

Abstract excerpt

BACKGROUND: Aseptic loosening is the major cause of long-term failure of an arthroplasty. Pathophysiological periprosthetic osteolysis is driven by wear debris particles (WDP) accumulating in the surrounding joint tissues. Macrophages, professional phagocytic cells, internalise submicron WDP and upregulate production of inflammatory mediators, stimulating circulating monocytes to migrate into the inflamed joint ti...

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Literature Corpus work
861f52cd-82df-5f68-bb43-822ae594c0e6
DOI
10.17638/03034099
Open publication

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