Article
A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer.
Molecular and cellular biology - 1 Sept 1995
Zhang Y, Rollins B J
Abstract excerpt
Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family of proinflammatory cytokines, all of which share a high degree of amino acid sequence similarity. Aberrant expression of chemokines occurs in a variety of diseases that have an inflammatory component, such as atheroscl...
Topics
- Base Sequence
- Binding, Competitive
- Chemokine CCL2
- Chemotactic Factors
- Chemotaxis, Leukocyte
- Cross-Linking Reagents
- Cytokines
- Dose-Response Relationship, Drug
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Sequence Deletion
- Solutions