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Article

Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.

Biomaterials - 1 Feb 2017

Nabeshima Akira, Pajarinen Jukka, Lin Tzu-Hua, Jiang Xinyi, Gibon Emmanuel, Córdova Luis A, Loi Florence, Lu Laura, Jämsen Eemeli, Egashira Kensuke, Yang Fan, Yao Zhenyu, Goodman Stuart B

Abstract excerpt

Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the most important chemokine regulating trafficking of monocyte/macrophages in particle-induced inflammation. 7ND recombinant protein is a mutant of CCL2 that inhibits CCL2 signaling. We have...

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Identifiers

PMID: 27918885
DOI: 10.1016/j.biomaterials.2016.11.039
PMCID: PMC5180610

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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