A canonical EF-loop directs Ca(2+) -sensitivity in phospholipase C-η2.

Abstract excerpt

Phospholipase C-η (PLCη) enzymes are a class of phosphatidylinositol 4,5-bisphosphate-hydrolyzing enzymes involved in intracellular signaling. PLCη2 can sense Ca(2+) (stimulated by ∼1 µM free Ca(2+) ) suggesting that it can amplify transient Ca(2+) signals. PLCη enzymes possess an EF-hand domain composed of two EF-loops; a canonical 12-residue loop (EF-loop 1) and a non-canonical 13-residue loop (EF-loop 2)....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chlorocebus aethiops
• Share to Calcium