Article
Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1.
Biochemical and biophysical research communications - 30 Aug 2002
Lin Lin, Braunewell Karl-Heinz, Gundelfinger Eckart D, Anand Rene
Abstract excerpt
Visinin-like protein-1 (VILIP-1), a myristoylated calcium sensor protein with three EF-hand motifs, modulates adenylyl cyclase activity. It translocates to membranes when a postulated "calcium-myristoyl switch" is triggered by calcium-binding to expose its sequestered myristoyl moiety. We investigated the contributions of the EF-hand motifs to the translocation of VILIP-1 to membranes and to the modulation of...
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