Phospholipase C-η2 is activated by elevated intracellular Ca(2+) levels.

Abstract excerpt

Phospholipase C-η2 (PLCη2) is a novel enzyme whose activity in a cellular context is largely uncharacterised. In this study the activity of PLCη2 was examined via [(3)H]inositol phosphate release in COS7 cells expressing the enzyme. PLCη2 activity increased approximately 5-fold in response to monensin, a Na(+)/H(+) antiporter. This was significantly inhibited by CGP-37157 which implies that the effect of monensin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Calcium
• Share to Chlorocebus aethiops
• Share to COS Cells