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Article

Structural Basis of Protein Kinase Cα Regulation by the C-Terminal Tail.

Biophysical journal - 10 Apr 2018

Yang Yuan, Shu Chang, Li Pingwei, Igumenova Tatyana I

Abstract excerpt

Protein kinase C (PKC) isoenzymes are multi-modular proteins activated at the membrane surface to regulate signal transduction processes. When activated by second messengers, PKC undergoes a drastic conformational and spatial transition from the inactive cytosolic state to the activated membrane-bound state. The complete structure of either state of PKC remains elusive. We demonstrate, using NMR spectroscopy,...

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Identifiers

PMID: 29642029
DOI: 10.1016/j.bpj.2017.12.030
PMCID: PMC5954273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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