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Article

Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis.

The Journal of biological chemistry - 17 Oct 2008

Celić Andjelka, Petri Edward T, Demeler Borries, Ehrlich Barbara E, Boggon Titus J

Abstract excerpt

In polycystic kidney disease (PKD), polycystin-2 (PC2) is frequently mutated or truncated in the C-terminal cytoplasmic tail (PC2-C). The currently accepted model of PC2-C consists of an EF-hand motif overlapping with a short coiled coil; however, this model fails to explain the mechanisms by which PC2 truncations C-terminal to this region lead to PKD. Moreover, direct PC2 binding to inositol 1,4,5-trisphosphate...

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Source

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Identifiers

PMID: 18694932
DOI: 10.1074/jbc.M802743200
PMCID: PMC2568934

Genes

TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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