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Article

Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase.

Journal of neurochemistry - 1 Jan 2014

Li Rong, Xie Di-Dong, Dong Jun-Hong, Li Hui, Li Kang-Shuai, Su Jing, Chen Lai-Zhong, Xu Yun-Fei, Wang Hong-Mei, Gong Zheng, Cui Guo-Ying, Yu Xiao, Wang Kai, Yao Wei, Xin Tao, Li Min-Yong, Xiao Kun-Hong, An Xiao-Fei, Huo Yuqing, Xu Zhi-Gang, Sun Jin-Peng, Pang Qi

Abstract excerpt

Striatal-enriched tyrosine phosphatase (STEP) is an important regulator of neuronal synaptic plasticity, and its abnormal level or activity contributes to cognitive disorders. One crucial downstream effector and direct substrate of STEP is extracellular signal-regulated protein kinase (ERK), which has important functions in spine stabilisation and action potential transmission. The inhibition of STEP activity...

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Identifiers

PMID: 24117863
DOI: 10.1111/jnc.12463
PMCID: PMC3947313

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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