Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.

Molecular neurobiology - 1 Oct 2018

Bosco Federica, Valente Pierluigi, Milanese Marco, Piccini Alessandra, Messa Mirko, Bonanno Giambattista, Lombroso Paul, Baldelli Pietro, Benfenati Fabio, Giovedì Silvia

Abstract excerpt

The striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase involved in synaptic transmission. The current hypothesis on STEP function holds that it opposes synaptic strengthening by dephosphorylating and inactivating key neuronal proteins involved in synaptic plasticity and intracellular signaling, such as the MAP kinases ERK1/2 and p38, as well as the tyrosine kinase Fyn. Although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inositol 1,4,5-Trisphosphate Receptors

Share to Neostriatum

Share to Presynaptic Terminals

Share to Protein Tyrosine Phosphatases, Non-Receptor

Share to Synapsins

Share to Synaptosomes

Source

Identifiers

PMID: 29508281
DOI: 10.1007/s12035-018-0980-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.PMID 29508281Read ↗

Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase.Semantic proximity Read ↗

The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in CognitionSemantic proximity Read ↗

STEP inhibition prevents Aβ-mediated damage in dendritic complexity and spine density in Alzheimer’s disease.Semantic proximity Read ↗

The Protein Biochemistry of the Postsynaptic Density in Glutamatergic Synapses Mediates Learning in Neural Networks.Semantic proximity Read ↗

Rasopathy-Associated Mutation Ptpn11D61Y has Age-Dependent Effect on Synaptic Vesicle Recycling.Semantic proximity Read ↗

Proteomics of brain synapses and molecular dissection of synaptic subdomains.Semantic proximity Read ↗

Postsynaptic serine racemase regulates NMDA receptor functionSemantic proximity Read ↗

PINK1 heterozygous mutations induce subtle alterations in dopamine‐dependent synaptic plasticitySemantic proximity Read ↗

Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.Semantic proximity Read ↗

The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals.Semantic proximity Read ↗

Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.Semantic proximity Read ↗

Cell-type specific visualization and biochemical isolation of endogenous synaptic proteins in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.