Article
Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase.
Science (New York, N.Y.) - 22 May 1998
Camps M, Nichols A, Gillieron C, Antonsson B, Muda M, Chabert C, Boschert U, Arkinstall S
Abstract excerpt
MAP kinase phosphatase-3 (MKP-3) dephosphorylates phosphotyrosine and phosphothreonine and inactivates selectively ERK family mitogen-activated protein (MAP) kinases. MKP-3 was activated by direct binding to purified ERK2. Activation was independent of protein kinase activity and required binding...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Calcium-Calmodulin-Dependent Protein Kinases
- Catalysis
- Dual Specificity Phosphatase 6
- Enzyme Activation
- Epidermal Growth Factor
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 12
- Mitogen-Activated Protein Kinase 9
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data