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Article

Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.

Cell reports - 26 Dec 2017

Zhu Jinwei, Zhou Qingqing, Shang Yuan, Li Hao, Peng Mengjuan, Ke Xiao, Weng Zhuangfeng, Zhang Rongguang, Huang Xuhui, Li Shawn S C, Feng Guoping, Lu Youming, Zhang Mingjie

Abstract excerpt

The PSD-95/SAPAP/Shank complex functions as the major scaffold in orchestrating the formation and plasticity of the post-synaptic densities (PSDs). We previously demonstrated that the exquisitely specific SAPAP/Shank interaction is critical for Shank synaptic targeting and Shank-mediated synaptogenesis. Here, we show that the PSD-95/SAPAP interaction, SAPAP synaptic targeting, and SAPAP-mediated synaptogenesis...

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PMID: 29281827
DOI: 10.1016/j.celrep.2017.11.107

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PSD

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