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Article

Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Oct 2008

Bettencourt da Cruz Alexandre, Wentzell Jill, Kretzschmar Doris

Abstract excerpt

The Drosophila Swiss Cheese (SWS) protein and its vertebrate ortholog Neuropathy Target Esterase (NTE) are required for neuronal survival and glial integrity. In humans, NTE is the target of organophosphorous compounds which cause a paralyzing axonal degeneration and recently mutations in NTE hav...

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Source

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Identifiers

PMID: 18945896
DOI: 10.1523/JNEUROSCI.3015-08.2008
PMCID: PMC2723165

Genes

C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18945896-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.PMID 18945896Read ↗

The cyclic nucleotide binding sites of Swiss-Cheese, the <i>Drosophila</i> orthologue of human PNPLA6, are required for its catalytic functionSemantic proximity Read ↗

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.Semantic proximity Read ↗

Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.Semantic proximity Read ↗

Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolismSemantic proximity Read ↗

Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.Semantic proximity Read ↗

A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline.Semantic proximity Read ↗

Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.Semantic proximity Read ↗

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.Semantic proximity Read ↗

Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.Semantic proximity Read ↗

Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.Semantic proximity Read ↗

NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.Semantic proximity Read ↗

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the RIβ-L50R variant is expressedSemantic proximity Read ↗

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