Article

STEP inhibition prevents Aβ-mediated damage in dendritic complexity and spine density in Alzheimer’s disease.

2020-04-03

Abstract excerpt

Loss of dendritic spines and decline of cognitive function are hallmarks of patients with Alzheimer’s disease (AD). Previous studies have shown that AD pathophysiology involves increased expression of a central nervous system-enriched protein tyrosine phosphatase called STEP (STriatal-Enriched protein tyrosine Phosphatase). STEP opposes the development of synaptic strengthening by dephosphorylating substrates, inc...

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Literature Corpus work: bb3b177b-e63f-5aa2-acf0-35f3c917e27f
DOI: 10.1101/2020.04.02.022749

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