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Article

Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin.

PloS one - 1 Jan 2013

Baksi Shounak, Jana Nihar R, Bhattacharyya Nitai Pada, Mukhopadhyay Debashis

Abstract excerpt

Growth factor receptor protein binding protein 2 (Grb2) is known to be associated with intracellular growth and proliferation related signaling cascades. Huntingtin (Htt), a ubiquitously expressed protein, when mutated, forms toxic intracellular aggregates - the hallmark of Huntington's disease (HD). We observed an elevated expression of Grb2 in neuronal cells in animal and cell models of HD. Grb2 overexpression...

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Identifiers

PMID: 24116161
DOI: 10.1371/journal.pone.0076792
PMCID: PMC3792889

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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