Article

Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

2020-05-30

Abstract excerpt

Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription factor XBP1, a key mediator of the ER stress response, delays disease progression and reduces protein aggregation in various models of neurodegeneration. To identify disease-modifier genes that may...

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Literature Corpus work: d3c31a03-f7f8-5f75-ac46-3de9da09d220
DOI: 10.1101/2020.05.28.119164

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