Article
The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.
EMBO molecular medicine - 1 Feb 2013
Moreira Sousa Cristovão, McGuire John Russel, Thion Morgane Sonia, Gentien David, de la Grange Pierre, Tezenas du Montcel Sophie, Vincent-Salomon Anne, Durr Alexandra, Humbert Sandrine
Abstract excerpt
In Huntington disease (HD), polyglutamine expansion in the huntingtin protein causes specific neuronal death. The consequences of the presence of mutant huntingtin in other tissues are less well understood. Here we propose that mutant huntingtin influences breast cancer progression. Indeed, we sh...
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