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Article

Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.

Human molecular genetics - 1 Aug 2007

Scappini Erica, Koh Tong-Wey, Martin Negin P, O'Bryan John P

Abstract excerpt

Huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt) resulting in aggregation of mutant Htt into nuclear and/or cytosolic inclusions in neurons. Mutant Htt affects multiple processes including protei...

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Identifiers

PMID: 17550941
DOI: 10.1093/hmg/ddm134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17550941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.PMID 17550941Read ↗

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.Semantic proximity Read ↗

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Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s DiseaseSemantic proximity Read ↗

Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.Semantic proximity Read ↗

HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity.Semantic proximity Read ↗

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.Semantic proximity Read ↗

Ataxin-2 Disordered Region Promotes Huntingtin Protein Aggregation And Neurodegeneration In Drosophila Models Of Huntington’s DiseaseSemantic proximity Read ↗

p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity.Semantic proximity Read ↗

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.Semantic proximity Read ↗

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.Semantic proximity Read ↗

BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution.Semantic proximity Read ↗

The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation.Semantic proximity Read ↗

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