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Article

Mutant huntingtin regulates EGF receptor fate in non-neuronal cells lacking wild-type protein.

Biochimica et biophysica acta - 1 Jan 2013

Melone Mariarosa A B, Calarco Anna, Petillo Orsolina, Margarucci Sabrina, Colucci-D'Amato Luca, Galderisi Umberto, Koverech Guido, Peluso Gianfranco

Abstract excerpt

Huntingtin (htt) is a scaffold protein localized at the subcellular level and is involved in coordinating the activity of several protein for signaling and intracellular transport. The emerging properties of htt in intracellular trafficking prompted us to study the role of mutant htt (polyQ-htt) in the intracellular fate of epidermal growth factor receptor (EGFR), whose activity seems to be strictly regulated by...

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Source

Identifiers

PMID: 22974559
DOI: 10.1016/j.bbadis.2012.09.001

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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