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Article

Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.

The international journal of biochemistry & cell biology - 1 Jan 2017

Banerjee Manisha, Datta Moumita, Bhattacharyya Nitai P

Abstract excerpt

Increased poly glutamine (polyQ) stretch at N-terminal of Huntingtin (HTT) causes Huntington's disease. HTT interacts with large number of proteins, although the preference for such interactions with wild type or mutated HTT protein remains largely unknown. HYPK, an intrinsically unstructured protein chaperone and interactor of mutant HTT was found to interact with myeloid leukemia factor 1 (MLF1) and 2 (MLF2)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27840155
DOI: 10.1016/j.biocel.2016.11.008

Genes

HTT
MLF1
MLF2
HYPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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