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Article

Arfaptin 2 regulates the aggregation of mutant huntingtin protein.

Nature cell biology - 1 Mar 2002

Peters Peter J, Ning Ke, Palacios Felipe, Boshans Rita L, Kazantsev Aleksey, Thompson Leslie M, Woodman Ben, Bates Gillian P, D'Souza-Schorey Crislyn

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder. Here we demonstrate that expression of arfaptin 2/POR1 (partner of Rac1) in cultured cells induces the formation of pericentriolar and nuclear aggregates, which morphologically resemble mutant huntingtin aggregates characteristic of HD. Endogenous arfaptin 2 localizes to aggregates induced by expression of an abnormal amino-terminal fragment of...

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PMID: 11854752
DOI: 10.1038/ncb761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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