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Article

Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.

Journal of molecular neuroscience : MN - 1 Sept 2013

Drost Jessica, Nonis David, Eich Florian, Leske Oliver, Damrath Ewa, Brunt Ewout R, Lastres-Becker Isabel, Heumann Rolf, Nowock Joachim, Auburger Georg

Abstract excerpt

Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src. Gain of function of ATXN2 leads to neuronal atrophy in the diseases spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS). Conversely, ATXN2 knockout...

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Source

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Identifiers

PMID: 23335000
DOI: 10.1007/s12031-012-9949-4
PMCID: PMC3739869

Genes

ATXN2
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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