Article
Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3).
Oncotarget - 29 Nov 2016
Amessou Mohamed, Ebrahim Abdul Shukkur, Dilly Ashok, Joseph Melvin, Tabolina Marina, Chukkapalli Sahiti, Meroueh Louay, Syed Joseph T, Liddane Allison, Lang Siera Lanae, Al-Katib Ayad, Kandouz Mustapha
Abstract excerpt
The epidermal growth factor (EGF) receptor EGFR is a major receptor tyrosine kinase whose role in gliomagenesis is well established. We have recently identified EHD3 [Eps15 homology (EH) domain-containing protein 3], an endocytic trafficking regulatory protein, as a putative brain tumor suppressor. Here, we investigate the underlying mechanisms, by establishing a novel mechanistic and functional connection...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.