Article
Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Feb 2018
Cardinale A, Fusco F R, Paldino E, Giampà C, Marino M, Nuzzo M T, D'Angelo V, Laurenti D, Straccia G, Fasano D, Sarnataro D, Squillaro T, Paladino S, Melone Mariarosa A B
Abstract excerpt
Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters. Several studies have highlighted its endogenous neuroprotective function. Huntington's disease (HD), a dominant hereditary disease, is characterized by the gradual loss of neurons in discrete areas of the central nervous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.